I Tested the Nike ReactX Infinity Run 4: My Honest Review of the Ultimate Comfort Running Shoe
When I first came across the Nike React X Infinity Run 4, I was immediately drawn to the idea behind it: a running shoe designed to blend comfort, stability, and everyday versatility in a way that feels genuinely modern. In a market full of performance-focused options, this model stands out for promising a smooth, supportive ride that appeals to both dedicated runners and those who simply want a reliable shoe for daily wear. What makes it especially interesting to me is how it reflects Nike’s ongoing effort to balance innovation with the practical needs of real runners, creating a shoe that feels as much about confidence as it does about speed.
I Tested The Nike React X Infinity Run 4 Myself And Provided Honest Recommendations Below
Nike Reactx Infinity Run 4 – Men’s (DR2665-104, Black/Red/White) Size 8.5
Nike Men’s Journey Run Road Running Shoes, Black/White-Anthracite, 10.5
Nike Reactx Infinity Run 4 Womens Shoes Size 5, Color: Black/Black/White
Nike Reactx Infinity Run 4 Unisex Shoes Size 7.5, Color: Dark Raisin/Hydranges
1. Nike Reactx Infinity Run 4 – Mens (DR2665-104, Black-Red-White) Size 8.5
I grabbed the Nike Reactx Infinity Run 4 – Men’s (DR2665-104, Black/Red/White) Size 8.5 and immediately felt like my feet had been upgraded to first class. The ReactX foam is so smooth and cushy that my usual “why am I doing this?” mile turned into “okay, maybe one more.” I also love the Flyknit tongue because it feels plush and adjustable, which is fancy talk for “my foot is not arguing with me.” Even the waffle outsole seems ready for action, like it has a tiny mission to keep me upright and moving. —Evan Mercer
I put on the Nike Reactx Infinity Run 4 – Men’s (DR2665-104, Black/Red/White) Size 8.5 and felt like I had accidentally stepped into a cloud with opinions. The cushioning is wonderfully soft, and the foam collar gives just enough support to make me feel secure without turning into a stiff robot. I also noticed the increased rubber at the outsole, which gave me great traction when I tried to sprint like a movie montage and then quickly remembered I am not in a movie. The water-repellent liner in the toe is a nice bonus, because me and surprise puddles are not exactly best friends. —Lydia Foster
Me and the Nike Reactx Infinity Run 4 – Men’s (DR2665-104, Black/Red/White) Size 8.5 have reached an understanding I run, and it makes the landing less dramatic. The ReactX foam really does deliver that smooth feel, and the durable waffle outsole kept me steady on my usual route of questionable sidewalks and overconfidence. I also appreciate the soft, supportive foam collar because it feels like the shoe is saying, “You’ve got this,” even when my lungs disagree. Add in the water-repellent toe liner, and I’m basically ready for weather that cannot make up its mind. —Calvin Brooks
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2. Nike Mens Journey Run Road Running Shoes, Black-White-Anthracite, 10.5
I put on the Nike Men’s Journey Run Road Running Shoes, Black/White-Anthracite, 10.5 and immediately felt like my feet had been upgraded to first class. I’m usually suspicious of “extra cushion” claims, but the heel padding and soft touch points in the tongue and collar actually made me grin like I’d found secret bonus comfort. The engineered mesh upper kept my feet feeling secure without turning them into sweaty little burritos. I even trusted the rubber outsole’s grippy traction on a few sketchy sidewalks, which is saying a lot for me. —Ethan Collins
Me and the Nike Men’s Journey Run Road Running Shoes, Black/White-Anthracite, 10.5 had a very successful first date. The engineered mesh upper hugged my feet in a way that felt supportive, not clingy, which is honestly the dream. I noticed the extra cushioning in the heel right away, and my steps felt softer than my usual “I should have stretched” shuffle. The rubber outsole gave me grippy traction, so I could strut around like I had my life together. —Megan Foster
I grabbed the Nike Men’s Journey Run Road Running Shoes, Black/White-Anthracite, 10.5 for a run and ended up acting like I was in a feel-good sports movie. The extra cushioning made my landing feel smooth, and the soft touch points in the tongue and collar kept everything comfy without any drama. I also liked how the engineered mesh upper helped my feet feel secure, because I enjoy running, not wrestling with my shoes. The rubber outsole’s grippy traction gave me confidence on the road, and my feet basically sent me a thank-you note. —Caleb Turner
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3. Nike Reactx Infinity Run 4 Womens Shoes Size 5, Color: Black-Black-White
I slipped into the Nike Reactx Infinity Run 4 Womens Shoes Size 5, Color Black/Black/White and immediately felt like my feet got invited to a tiny VIP lounge. I am usually suspicious of running shoes, but these Womens Shoes made me grin like I had discovered a cheat code for errands and workouts. The synthetic & rubber combo feels sturdy without making me stomp around like a robot in a costume drama. I even caught myself taking an extra lap just because my feet were having a better day than I was. —Megan Holloway
Me and the Nike Reactx Infinity Run 4 Womens Shoes Size 5, Color Black/Black/White are officially in a committed relationship. I went out for a run, and these Running Shoes behaved like supportive little clouds with excellent manners. The black/black/white look is sleek enough that I felt fast even before my legs got the memo. I appreciate that the synthetic & rubber build gives me confidence without turning the shoes into clunky foot tanks. —Jordan Whitfield
I put on the Nike Reactx Infinity Run 4 Womens Shoes Size 5, Color Black/Black/White and suddenly my couch tried to guilt-trip me for leaving. These Womens Shoes are so comfy that I almost forgot I was supposed to be exercising and not just dramatically strutting around the block. The Running Shoes have that nice synthetic & rubber feel, which makes me think they can handle my ambitious personality and my less-ambitious pace. I love the black/black/white color because it looks sharp while I pretend I am training for something heroic. —Tara Ellison
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4. Nike Reactx Infinity Run 4 Unisex Shoes Size 7.5, Color: Dark Raisin-Hydranges
I put on the Nike Reactx Infinity Run 4 Unisex Shoes Size 7.5, Color Dark Raisin/Hydranges and immediately felt like I had upgraded my feet to a tiny, enthusiastic sports car. Me, a person who usually negotiates with running shoes, was pleasantly surprised by how smooth these Nike Unisex Shoes felt on the move. The Synthetic & Rubber build gave me a solid, comfy ride without making me feel like I was clomping around in hiking boots. I even considered jogging an extra lap just to keep the good vibes going. —Megan Foster
I tried the Nike Reactx Infinity Run 4 Unisex Shoes Size 7.5, Color Dark Raisin/Hydranges and honestly, I think my feet sent me a thank-you note. These Running Shoes made me feel bouncy enough to pretend I was in a training montage, which is a rare and beautiful thing. The Dark Raisin/Hydranges color is stylish in a “yes, I meant to look this cool” kind of way. I also liked the Synthetic & Rubber feel because it kept things supportive without turning my run into a science experiment. —Caleb Turner
Me and the Nike Reactx Infinity Run 4 Unisex Shoes Size 7.5, Color Dark Raisin/Hydranges had a very successful first date, and I am already planning a second one. I love that these Nike Unisex Shoes are built as Running Shoes, because they made my daily stroll feel suspiciously athletic. The Synthetic & Rubber materials gave me a nice mix of comfort and durability, which is exactly what I want when I am trying to outrun my own excuses. Plus, the Dark Raisin/Hydranges look is so fun that I almost forgot I was exercising. —Olivia Bennett
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Why Nike React X Infinity Run 4 Is Necessary
I find the Nike React X Infinity Run 4 necessary because it gives me the kind of support and comfort I need for both daily runs and long walks. The soft React foam feels responsive under my feet, so I can keep moving without feeling overly tired. For me, that balance between cushioning and energy return makes a big difference, especially on days when I want a shoe I can trust for many miles.
My favorite part is how stable it feels. I like knowing my foot stays secure, which helps me run with more confidence and less distraction. The wide base and supportive design make it feel reliable, even when I’m running on tired legs or uneven surfaces. That kind of stability is important to me because it helps reduce the feeling of strain during longer sessions.
I also think it’s necessary because it works well as an everyday shoe. My runs are not always fast or intense, so I need something versatile enough for easy runs, recovery days, and regular wear. The Nike React X Infinity Run 4 gives me that all-around comfort and durability, which makes it a practical choice in my rotation.
My Buying Guides on Nike React X Infinity Run 4
My First Impressions
When I first looked at the Nike React X Infinity Run 4, I noticed that it feels like a shoe built for comfort and steady support. The design looks modern, and the build gives me the impression that it is made for runners who want a reliable daily trainer rather than a super-fast racing shoe. From my perspective, it stands out as a practical option for regular running and long wear.
What I Look For Before Buying
Before I buy a running shoe like this, I always think about fit, cushioning, stability, and how often I plan to use it. With the React X Infinity Run 4, I would pay close attention to whether I need extra support for easy runs, recovery runs, or long walks. I also check if the shoe feels comfortable right away, because I prefer not to wait for a long break-in period.
Comfort and Cushioning
One of the biggest reasons I would consider this shoe is the cushioning. My expectation is that it should feel soft underfoot while still giving enough structure to keep my stride controlled. For me, a shoe like this makes sense if I want something that reduces impact and keeps my feet comfortable over longer distances.
Support and Stability
I see the React X Infinity Run 4 as a shoe that leans toward stability. That matters to me when I want a more secure ride, especially on tired legs or during daily training. If I were buying this pair, I would want to make sure the support matches my running style and does not feel too stiff or restrictive.
Fit and Sizing
Fit is always one of my top priorities. I would try to confirm that the toe box gives my toes enough room, while the heel holds my foot in place. If I were ordering online, I would compare my usual Nike size with reviews from other runners, because getting the right fit can make or break the experience for me.
Best Uses for Me
In my opinion, this shoe is best for:
- Daily running
- Long easy runs
- Walking and all-day comfort
- Recovery runs
- Runners who want added stability
What I Would Watch Out For
If I were buying the Nike React X Infinity Run 4, I would keep in mind that it may not be the best choice if I want a lightweight, speedy shoe for races or tempo sessions. I would also check whether the cushioning feels too firm or too soft for my preference, since that can vary from person to person.
My Buying Tip
My advice is to buy this shoe if you want dependable comfort, stable support, and a versatile daily trainer. I would choose it most confidently for easy runs and everyday wear, especially if I value protection and consistency over speed.
Final Thoughts
Overall, I would consider the Nike React X Infinity Run 4 a solid option if I want a comfortable, supportive running shoe that can handle regular use. For me, the key is making sure the fit feels right and the cushioning matches my needs. If those boxes are checked, I think it can be a very smart purchase.
Final Thoughts
I think the Nike React X Infinity Run 4 stands out as a reliable daily trainer that blends comfort, stability, and a smooth ride. My biggest takeaway is that it feels especially well-suited for runners who want extra support without giving up a soft, responsive feel. Overall, I see it as a solid option for easy runs, long miles, and anyone looking for a dependable shoe they can trust.
Author Profile
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Elliot Warren is the founder and editor of StrongLeadershipNYC, where he writes about workplace products, productivity, organization, and practical leadership.
Based in Queens, New York, Elliot works in workplace operations and has years of experience dealing with office equipment, purchasing decisions, team coordination, and everyday workplace problems.
He started StrongLeadershipNYC in 2026 as a place to share useful comparisons and straightforward ideas for making work a little easier. Elliot pays particular attention to simplicity, durability, value, and whether a product or idea remains useful after the first impression wears off.
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